GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs548181 | 1 | rs548181 | chr11:125461709 | PUS3 | chr11:125763380-125773116:- | -0.25 | -3.4 | 0.000719 | Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined);Schizophrenia |
| THCA | cis | rs477692 | 1 | rs548390 | chr10:131417427 | MGMT | chr10:131265454-131565783:+ | 0.38 | 11.35 | 1.28E-26 | Response to temozolomide |
| THCA | cis | rs7116495 | 1 | rs548961 | chr11:71793887 | FAM86C | chr11:71498557-71512276:+ | 0.3 | 3.69 | 0.000248 | Severe influenza A (H1N1) infection |
| THCA | cis | rs2786111 | 1 | rs550098 | chr1:197297408 | CFHR3 | chr1:196743930-196762872:+ | 0.25 | 5.1 | 4.88E-7 | Lupus nephritis in systemic lupus erythematosus |
| THCA | cis | rs17780086 | 1 | rs550213 | chr17:30317518 | C17orf79 | chr17:30178885-30186326:- | -0.18 | -4.32 | 1.93E-5 | Height |
| THCA | cis | rs800292 | 1 | rs551397 | chr1:196642072 | CFHR3 | chr1:196743930-196762872:+ | 0.25 | 4.73 | 3.03E-6 | Circulating myeloperoxidase levels (serum) |
| THCA | cis | rs477692 | 1 | rs553371 | chr10:131413676 | MGMT | chr10:131265454-131565783:+ | 0.38 | 11.44 | 6.05E-27 | Response to temozolomide |
| THCA | cis | rs8180040 | 1 | rs553989 | chr3:47400328 | C3orf75 | chr3:47537131-47555199:- | 0.09 | 4.25 | 2.6E-5 | Colorectal cancer |
| THCA | cis | rs8180040 | 1 | rs553989 | chr3:47400328 | NBEAL2 | chr3:47021173-47051193:+ | 0.12 | 3.7 | 0.000245 | Colorectal cancer |
| THCA | cis | rs8180040 | 1 | rs553989 | chr3:47400328 | PRSS45 | chr3:46783582-46790130:- | 0.16 | 3.53 | 0.00045 | Colorectal cancer |
| THCA | cis | rs599083 | 1 | rs554734 | chr11:68192518 | LOC645332 | chr11:67559240-67572807:- | 0.16 | 3.5 | 0.000514 | Bone mineral density (spine) |
| THCA | cis | rs477692 | 1 | rs554792 | chr10:131423181 | MGMT | chr10:131265454-131565783:+ | 0.38 | 11.31 | 1.9E-26 | Response to temozolomide |
| THCA | cis | rs555044 | 1 | rs555044 | chr12:335922 | CCDC77 | chr12:498516-551804:+ | -0.23 | -3.71 | 0.000229 | Serum metabolite levels |
| THCA | cis | rs976337 | 1 | rs555152 | chr11:95016478 | KDM4D | chr11:94706845-94732674:+ | -0.16 | -3.34 | 0.000903 | Positive affect |
| THCA | cis | rs683250 | 1 | rs556199 | chr11:83276006 | CCDC90B | chr11:82972506-82997414:- | 0.16 | 3.94 | 9.49E-5 | Subcortical brain region volumes |